Ph.D (Chemistry), FRSC (London UK)
University of Burdwan, Burdwan, India.
M.Sc, Organic Chemisty
University of Burdwan, Burdwan, India.
B.Sc, Chemistry (Hons)
University of Burdwan, Burdwan, India.
Work Experiences
1. Industrial experience: 7.5 yrs (from 1994 to July'2002)
2. Lecturer in chemistry (WBES) in A. B. N. Seal College, CoochBehar (2002- 2006)
3.Lecturer (Sr Scale) in chemistry (WBES) in A. B. N. Seal College, CoochBehar 2006- 2007.
4. Joined as Lecturer (Sr Scale) in Chemistry - March '2007 in NIT Durgapur.
5. Assistant Professor, NIT Durgapur- 2009-2012.
6. Associate Professor in NIT Durgapur from 2012- 2018.
7. Professor in chemistry from Oct' 2018 to till date.
8. Head, Department of Chemistry since July2021 to till date.
Research Interest
1. Pt(II) and Pd(II based anticancer drug design and drug development.
2. Synthesis of Pt(II) and Pd(II) complexes, analogous to platinum based anticancer drugs with comparable or better cytotoxic property on Cancer cell lines; DNA/protein binding, In vitro cytotoxic study on cancer cell lines as well as normal cell.
3. Special emphasis on kinetics and mechanism of biologically important Inorganic reactions.
4. Theoretical investigations (DFT) such as geometry optimisation, TD-DFT, reactivity parameters, IRC, NBO etc.
Projects
Title
Investigator
Co-investigator
Sponsered Agency
Duration
Status
Current Government Sponsored Projects (Last 5 Years)
SL No
Current Position
From-To
PI or Co-PI
Sponsoring agency
Amount in Rs.
1.
Completed
2017- 2020
Sole PI
DST-SERB, Government of India
44,66,000
2.
Ongoing
2017-2020
Sole PI
DHESTBT, Govt of West Bengal
24,99,100
3.
Ongoing
2018-2021
Sole PI
CSIR, Government of India
10,30,000
4.
Completed
2013-2017
Sole PI
DST-SERB, Government of India
42,59,200
Ongoing
Teachings
Teaching Experience:
Total Teaching Experience: 20 yrs +
(i) B. Tech, M. Tech. (Corrosion Science and Technology) and M. Sc. Chemistry, (13 yrs+)
Teaching interest: B. Tech Classes:
Organic Reaction Mechanism; Polymer Chemistry and Engineering; Petroleum Chemistry and Engineering; Quantitative analysis of Inorganic samples, Qualitative analysis of Organic compounds; Application of Analytical Instruments in engineering sample analysis (Elective paper in 8th Sem. B. Tech.)
M. Tech in Corrosion Science and Technology:
Material protectives and organic coating (Polymer including Rubber and plastic Science and technology, Composite and Laminates (1st Sem.). Industrial corrosion (Thermal power Plant and Pulp and paper Industry). (Course stopped from July'2018)
M. Sc. Chemistry:
a. Stereochemistry and application in synthesis of Bio relevant organic molecules.
b. Uses of Special Reagents in Organic Synthesis.
c. Important reaction in Organic Chemistry and their applications.
Venkata Pera Reddy B. (Reg. NO: NITD/Ph. D/CH/2015/00631) Thesis title: "An experimental and theoretical investigation on Pt(II) and Pd(II) complexes: their cytotoxic activity, kinetics, mechanism and DFT study" Total Paper published 21 Ph. D. Thesis submitted.
Reg. No: NITD/Ph. D/CH/2015/00631
Title of the thesis: An Experimental And Theoretical Investigation On
Pt(Ii) And Pd(Ii) Complexes: Their Cytotoxic Activity, Kinetics, Mechanism And
DFT Study
Mr. Venkata Pera Reddy B.
Ph. D.
Venkata Pera Reddy B. (Reg. NO: NITD/Ph. D/CH/2015/00631) Thesis title: "An experimental and theoretical investigation on Pt(II) and Pd(II) complexes: their cytotoxic activity, kinetics, mechanism and DFT study" Total Paper published 21 Ph. D. Thesis submitted.
Reg. No: NITD/Ph. D/CH/2015/00631
Title of the thesis: An Experimental And Theoretical Investigation On
Pt(Ii) And Pd(Ii) Complexes: Their Cytotoxic Activity, Kinetics, Mechanism And
DFT Study
Mr. Saikat Mandal
Ph. D degree will be conferred in the next convocation- 2023
Synthesis and characterization of Pt(II) & Pd(II) complexes as anticancer drug candidates: their DNA,BSA binding activity, anticancer property and theoretical aspects
“Bioactivity and cytotoxic property of Pt(II)
& Pd(II) complexes with different (N, N) bidentate chelates: their
bio-physical analysis on DNA/BSA binding, molecular docking and theoretical
aspects”
Mr. Saikat Mandal
Ph. D degree will be conferred in the next convocation- 2023
Synthesis and characterization of Pt(II) & Pd(II) complexes as anticancer drug candidates: their DNA,BSA binding activity, anticancer property and theoretical aspects
“Bioactivity and cytotoxic property of Pt(II)
& Pd(II) complexes with different (N, N) bidentate chelates: their
bio-physical analysis on DNA/BSA binding, molecular docking and theoretical
aspects”
Miss. Angana Pan
On going Ph. D (Ongoing)
Applied for INSPIRE research Fellowship, joined in January'2018. She has INSPIRE up to M. Sc. (Hons). Working on "Synthesis, characterization of Pt(II) and Pd(II) complexes with hetero bidentate ligands having anticancer activity on different cancer cell lines and less toxic on Normal cell. Mainly emphasized on Kinetics, Mechanism and Bio-activity along with Theoretical DFT study".
“Synthesis and characterization of Pt(II)
& Pd(II)complexes with piperidine based carrier ligand: their bioactivity,
anticancer property and theoretical insights"Reg. No. 20RCY010 and Roll
No: 18CY1105
Miss. Angana Pan
On going Ph. D (Ongoing)
Applied for INSPIRE research Fellowship, joined in January'2018. She has INSPIRE up to M. Sc. (Hons). Working on "Synthesis, characterization of Pt(II) and Pd(II) complexes with hetero bidentate ligands having anticancer activity on different cancer cell lines and less toxic on Normal cell. Mainly emphasized on Kinetics, Mechanism and Bio-activity along with Theoretical DFT study".
“Synthesis and characterization of Pt(II)
& Pd(II)complexes with piperidine based carrier ligand: their bioactivity,
anticancer property and theoretical insights"Reg. No. 20RCY010 and Roll
No: 18CY1105
Mr. Swarup Kumar Tarai
Ph. D Thesis submitted
Institute Research fellow, joined in January'2018. He is NET-2017 and GATE-2015 qualified. Working on "Synthesis, characterization of Pt(II) and Pd(II) complexes having anticancer activity and less toxic on Normal cell. Kinetics, Mechanism and Bio-activity along with Theoretical DFT study".
"Synthesis and characterization of pyrrolidine based Pt(II) & Pd(II)
complexes as anticancer drug candidates: their theoretical investigations and
bioactivity study"
Mr. Swarup Kumar Tarai
Ph. D Thesis submitted
Institute Research fellow, joined in January'2018. He is NET-2017 and GATE-2015 qualified. Working on "Synthesis, characterization of Pt(II) and Pd(II) complexes having anticancer activity and less toxic on Normal cell. Kinetics, Mechanism and Bio-activity along with Theoretical DFT study".
"Synthesis and characterization of pyrrolidine based Pt(II) & Pd(II)
complexes as anticancer drug candidates: their theoretical investigations and
bioactivity study"
Miss Rituparna Bhaduri
Ph. D thesis submitted
DST-SERB Research fellow, joined in July 2018. She is GATE-2018 qualified and working on 'Bio transformation reactions of Pt(II)/Pd(II) and Pt(IV)-Sulfur chelates to metal-DNA adduct with nucleobases; their kinetics ,mechanistic pathway, bio-activity and theoretical aspects.'
Anticancer
activity of Pt(II) & Pd(II) complexes with pyridine scaffold: their
bio-molecular interactions, cell death mechanism and computational study
Miss Rituparna Bhaduri
Ph. D thesis submitted
DST-SERB Research fellow, joined in July 2018. She is GATE-2018 qualified and working on 'Bio transformation reactions of Pt(II)/Pd(II) and Pt(IV)-Sulfur chelates to metal-DNA adduct with nucleobases; their kinetics ,mechanistic pathway, bio-activity and theoretical aspects.'
Anticancer
activity of Pt(II) & Pd(II) complexes with pyridine scaffold: their
bio-molecular interactions, cell death mechanism and computational study
Miss. Chandraka Das
JRF, Institute Fellow
Synthesis and characterization of Pt(II) and Pd(II) based complexes with Heterocyclic diamines: their theoretical investigations, DNA and BSA binding and cytotoxic property.Roll No: 22CY1101
Not Yet fixed
Miss. Chandraka Das
JRF, Institute Fellow
Synthesis and characterization of Pt(II) and Pd(II) based complexes with Heterocyclic diamines: their theoretical investigations, DNA and BSA binding and cytotoxic property.Roll No: 22CY1101
Not Yet fixed
Sharmistha Chatterjee
JRF (Self sponsored Research Scholar)
Aromatic heterocyclic diamine chelated Pt(II) & Pd(II) complex synthesis and Characterization as anticancer drug candidates: their DNA and BSA binding, cytotoxic property and DFT studyRoll No: 22CY1107
Sharmistha Chatterjee
JRF (Self sponsored Research Scholar)
Aromatic heterocyclic diamine chelated Pt(II) & Pd(II) complex synthesis and Characterization as anticancer drug candidates: their DNA and BSA binding, cytotoxic property and DFT studyRoll No: 22CY1107
Mr. Sujoy Mahata
Ph. D completed
Part-Time Research fellow, joined in January'2016. He is NET-2017 and GATE-2015 qualified and working on "Synthesis, characterization of Pt(II) and Pd(II) complexes having anticancer activity and less toxic on Normal cell. Kinetics, Mechanism and Bio-activity along with Theoretical DFT study".
Mr. Sujoy Mahata
Ph. D completed
Part-Time Research fellow, joined in January'2016. He is NET-2017 and GATE-2015 qualified and working on "Synthesis, characterization of Pt(II) and Pd(II) complexes having anticancer activity and less toxic on Normal cell. Kinetics, Mechanism and Bio-activity along with Theoretical DFT study".
Dr. Koyel Misra
Ph. D. (Completed)
Pt(II) and Pd(II) based anticancer drug design and drug development: their synthesis, characterization, theoretical investigation, DNA, BSA binding study cell culture (both cancer cells and normal cell lines) , cell cycle arrest mechanism and molecular docking with macromolecules.
Kinetics and mechanism of substitution reactions on square planar Platinum and Palladium(II) complexes with sulfur containing ligands: their Bioactivity in aqueous medium.
Dr. Koyel Misra
Ph. D. (Completed)
Pt(II) and Pd(II) based anticancer drug design and drug development: their synthesis, characterization, theoretical investigation, DNA, BSA binding study cell culture (both cancer cells and normal cell lines) , cell cycle arrest mechanism and molecular docking with macromolecules.
Kinetics and mechanism of substitution reactions on square planar Platinum and Palladium(II) complexes with sulfur containing ligands: their Bioactivity in aqueous medium.
Dr. Subhajit Mukherjee
Ph. D. (Completed)
Pt(II) and Pd(II) based anticancer drug design and drug development: their synthesis, characterization, theoretical investigation, DNA, BSA binding study cell culture (both cancer cells and normal cell lines) , cell cycle arrest mechanism and molecular docking with macromolecules.
Dr. Subhajit Mukherjee
Ph. D. (Completed)
Pt(II) and Pd(II) based anticancer drug design and drug development: their synthesis, characterization, theoretical investigation, DNA, BSA binding study cell culture (both cancer cells and normal cell lines) , cell cycle arrest mechanism and molecular docking with macromolecules.
Dr. Ishani Mitra
Ph. D. (Completed)
Pt(II) and Pd(II) based anticancer drug design and drug development: their synthesis, characterization, theoretical investigation, DNA, BSA binding study cell culture (both cancer cells and normal cell lines) , cell cycle arrest mechanism and molecular docking with macromolecules.
Thesis title: Cytotoxic Pt(II) and Pd(II) complexes with heterocyclic carrier ligands: Synthesis, characterization, biological evaluation, kinetics and DFT study
Dr. Ishani Mitra
Ph. D. (Completed)
Pt(II) and Pd(II) based anticancer drug design and drug development: their synthesis, characterization, theoretical investigation, DNA, BSA binding study cell culture (both cancer cells and normal cell lines) , cell cycle arrest mechanism and molecular docking with macromolecules.
Thesis title: Cytotoxic Pt(II) and Pd(II) complexes with heterocyclic carrier ligands: Synthesis, characterization, biological evaluation, kinetics and DFT study
Dr. Avradeep Samanta
Ph. D. (Completed)
Dr. Avradeep Samanta
Ph. D. (Completed)
Dr. Goutam Kr. Ghosh
Ph. D. (Completed)
Dr. Goutam Kr. Ghosh
Ph. D. (Completed)
Projects
Sl.No.
Title
Name of the PI
Name of the CoPIs
Funding Agency
Amount (Rs.)
Project Type
Project Status
Date of Initiation
Date of Completion
1
"Searching of less toxic and more effective Cis-platin based new Pt(II) anticancer agents: Kinetics, DNA binding, bio-activity and DFT study"
Sankar Chandra Moi(sole)
NA
CSIR, Government of India
1,030,000
Sponsored
Ongoing
2018-11-30
2021
2
"Synthesis and characterization of Cis-platin based Pt/Pd(II) complexes: Their kinetics, mechanism, DNA- binding property and theoretical study" (Project file No: BT/ST/P/S&T/2G-44/2017).rnment Sponsored Projects
Sankar Chandra Moi(sole)
NA
DST-BT, Govt of West Bengal
2,499,100
Sponsored
Ongoing
2018-06-15
2020
3
Bio-transformation reactions of Pt(II)/Pd(II) and Pt(IV)-sulfur chelates to metal-DNA adduct with nucleobases: their kinetics, mechanistic pathway, bio-activity and theoretical aspects.Government Sponsored Projects
Sankar Chandra Moi (sole)
NA
DST-SERB, Government of India
4,466,000
Sponsored
Completed
2017-03-27
2021-06-26
4
SB/EMEQ-028/2013 Dated 08/07/2013; “Interaction of Bio-active Molecules with Pt(II) and Pd(II) complexes of bidentate supporting Ligands: Their Kinetics, mechanism and speciation study”
Sankar Chandra Moi(sole)
NA
DST-SERB, Government of India
4,259,200
Sponsored
Completed
2014-01-15
2018-01-14
Projects
Sl.No.
Title
Name of the PI
Name of the CoPIs
Funding Agency
Amount (Rs.)
Project Type
Project Status
Date of Initiation
Date of Completion
1
"Searching of less toxic and more effective Cis-platin based new Pt(II) anticancer agents: Kinetics, DNA binding, bio-activity and DFT study"
Sankar Chandra Moi(sole)
NA
CSIR, Government of India
1,030,000
Sponsored
Ongoing
2018-11-30
2021
2
"Synthesis and characterization of Cis-platin based Pt/Pd(II) complexes: Their kinetics, mechanism, DNA- binding property and theoretical study" (Project file No: BT/ST/P/S&T/2G-44/2017).rnment Sponsored Projects
Sankar Chandra Moi(sole)
NA
DST-BT, Govt of West Bengal
2,499,100
Sponsored
Ongoing
2018-06-15
2020
3
Bio-transformation reactions of Pt(II)/Pd(II) and Pt(IV)-sulfur chelates to metal-DNA adduct with nucleobases: their kinetics, mechanistic pathway, bio-activity and theoretical aspects.Government Sponsored Projects
Sankar Chandra Moi (sole)
NA
DST-SERB, Government of India
4,466,000
Sponsored
Completed
2017-03-27
2021-06-26
4
SB/EMEQ-028/2013 Dated 08/07/2013; “Interaction of Bio-active Molecules with Pt(II) and Pd(II) complexes of bidentate supporting Ligands: Their Kinetics, mechanism and speciation study”
1. Drug reservoir mechanism of Pt (II)-sulfur chelates
based on pharmacokinetics of Pt (II) complex with thiols &thio-ethers: An
experimental and theoretical approach Swarup Kumar Tarai, Rituparna Bhaduri, Subhajit Mukherjee, Saikat Mandal, Sankar Ch Moi* Inorg. Chimica Acta
517 & 120202
SCI
doi.org/10.1016/j.ica.2019.119117
Elsevier
Nhttps:// doi.org/10.1016/j.ica.2019.119117
29 August 2019
2023
2. Bioactivity,
molecular docking and anticancer behaviour of pyrrolidine based Pt(II)
complexes: their kinetics, DNA and BSA binding study by spectroscopic methods S. Kr. Tarai, S. Mandal, R. Bhaduri, A. Pan, P. Biswas, A. Bhattacharjee and S. C. Moi* Spectrochimica Acta Part A: Molecular and
Biomolecular Spectroscopy
287, 1, 122059
SCI
DOI: 10.1016/j.saa.2022.122059
Elsevier
DOI: 10.1016/j.saa.2022.122059
2023
2023
3. Photophysical study on DNA
& BSA binding and cytotoxic behaviour of piperidine-Pt(II) complexes: Their
kinetics & mechanism and molecular docking A. Pan, R. Bhaduri, S. Mandal, S. Kr. Tarai, A. Bagchi, A. Biswas and S. C. Moi* J. Photochem. Photobiol. A
441, 114740
SCI
https://doi.org/10.1016/j.jphotochem.2023.114740
Elsevier
https://doi.org/10.1016/j.jphotochem.2023.114740
2023
2023
4. Cytotoxic behavior and DNA/BSA binding activity of
thiosemicarbazone based Ni(II) complex: bio-physical, molecular docking and DFT
study. S. K. Tarai, A. Tarai, S. Mandal, B. Nath, I. Som, R. Bhaduri, A. Bagchi, S. Sarkar, A. Biswas and S. C. Moi,* J. Molecular
Liquids
383, 121921
SCI
https://doi.org/10.1016/j.molliq.2023.121921
Elsevier
https://doi.org/10.1016/j.molliq.2023.121921
2023
2023
5. Biophysical study on DNA and BSA binding
activity of Cu(II) complex: Synthesis, molecular docking, cytotoxic activity,
and theoretical approach S. Kr. Tarai1, S. Mandal, A. Tarai, I. Som, A. Pan, A. Bagchi, A. Biswas and S. C. Moi* Appl. Organomet Chem.
37, e7164
SCI
https://doi.org/10.1002/aoc.7164
Willy and Sons
https://doi.org/10.1002/aoc.7164
2023
2023
6. Pd(II) based anticancer
drug candidates with 1,2-Aminoethyl piperidine scaffold and sulfur donor
ancillary: Their in vitro bio-activity, molecular docking and DFT study A. Pan, S. Kr. Tarai , R. Bhaduri , S. Mandal and S. C. Moi * J. Molecular Liquids
386, 122421
SCI
https://doi.org/10.1016/j.molliq.2023.122421
Elsevier
https://doi.org/10.1016/j.molliq.2023.122421
2023
2023
7. Anticancer
Behavior of Pyrrolidine-Based Palladium(II) Complexes and Biophysical Approach
on Their DNA, BSA Binding Activity, Molecular Docking, and DFT Study S. Kumar Tarai, A. Pan, P. Biswas, R. Bhaduri, S. Mandal, A. Paul, S. Baitalik, A. Bhattacharjee, and S. C. Moi* Langmuir
39, 10947−10964
SCI
org/10.1021/acs.langmuir.3c01186
American Chemical Society (ACS)
https://doi.org/10.1021/acs.langmuir.3c01186
2023
2022
8. Theoretical hydrolysis mechanism of anticancer Pt
(II) and Pd (II) dichloro complexes with N, N bidentate chelator in aqueous
medium and their molecular docking S. Kr. Tarai, S. Mandal, R. Bhaduri, A. Pan, K. Misra, S. C. Moi* J. of chemical physics
553, 111390
SCI
https://doi.org/10.1016/j.chemphys.2021.111390
Elsevier
https://doi.org/10.1016/j.chemphys.2021.111390
2022
2022
9. Cytotoxic activity of
nitrogen, sulfur, and oxygen chelated Pt(II) complexes; their DNA/BSA binding
by in vitro and in silico approaches R. Bhaduri, S. Mandal, S. Kumar Tarai, A. Pan, S. Mukherjee, A. Bagchi, A. Biswas, S. C. Moi* J. Mol Liquids
360, 119529
SCI
https://doi.org/10.1016/j.molliq.2022.119529
Elsevier
https://doi.org/10.1016/j.molliq.2022.119529
2022
2022
10. Theoretical investigation
on hydrolysis mechanism of cis-platin analogous Pt(II)/Pd(II) complex by DFT
calculation and molecular docking approach for their interaction with DNA &
HSA S. Mandal, A. Pan, R. Bhaduri, S. Kr. Tarai, B. Singh Kapoor and S. C. Moi,* J.
Mol. Graphics and Modelling
117, 108314
SCI
https://doi.org/10.1016/j.jmgm.2022.108314
Elsevier
https://doi.org/10.1016/j.jmgm.2022.108314
2022
2022
11. In vitro anticancer
activity of Pd(II) complexes with pyridine scaffold: Their bioactivity, role in
cell cycle arrest, and computational study R. Bhaduri, A. Pan, S. Kr. Tarai, S. Mandal, A Bagchi, A Biswas and S. C. Moi* J. Molecular Liquids
367, 120540
SCI
https://doi.org/10.1016/j.molliq.2022.120540
Elsevier
https://doi.org/10.1016/j.molliq.2022.120540
2022
2022
12. Brief Research on the
Biophysical Study and Anticancer Behavior of Pt(II) Complexes: Their DNA/BSA
Binding, Molecular Docking, and Cytotoxic Property S. Mandal,§ S. Kr. Tarai,§ P. Patra, P. Nandi, S. Sing, B. Rajak, and S. C. Moi* Langmuir
38, 44, 13613–13625
SCI
https://doi.org/10.1021/acs.langmuir.2c02490
American Chemical Society (ACS)
https://doi.org/10.1021/acs.langmuir.2c02490
2022
2022
13. Cytotoxic
effects of Pd(II) complexes on cancer and normal cells: Their DNA & BSA
adduct formation and theoretical approaches: S. Mandal, S. Kr. Tarai, A. Pan, R. Bhaduri, P. Biswas, S. C. Moi,* Journal Bioorganic Chemistry
Vol: 128 Page:106093
SCI
org/10.1016/j.bioorg.2022.106093
Elsevier
2022
2022
14. Anticancer
property and normal cell toxicity profile of pyrrolidine-based platinum (II)
complexes: Their DNA, BSA interaction, and molecular docking. S. Kr. Tarai, A. Pan, S. Das, R. Bhaduri S, Mandal, S. Maitra, S. C. Moi* Appl Organomet Chem.
e6859.
SCI
doi.org/10.1002/aoc.6859
John Wiley and Son's
2022
2022
15. Theoretical
investigation on hydrolysis mechanism of cis-platin analogous Pt(II)/Pd(II)
complex by DFT calculation and molecular docking approach for their interaction
with DNA & HSA S. Mandal, A. Pan, R. Bhaduri, S. Kr. Tarai, B. Singh Kapoor; S C. Moi* J. Mol. Graphics and Modelling
Vol. 117 Page: 108314
SCI
https://doi.org/10.1016/j.jmgm.2022.108314
Elsevier
https://authors.elsevier.com/a/1fe~43ub-V2~WA
2022
2022
16. Cytotoxic activity of
nitrogen, sulfur, and oxygen chelated Pt(II) complexes; their DNA/BSA binding
by in vitro and in silico approaches J. Mol Liquids; 360 119529 (2022) R. Bhaduri, S. Mandal, S. Kumar Tarai, A. Pan, S. Mukherjee, A. Bagchi, A. Biswas, S. C. Moi* J. Mol Liquids
360 (2022) 119529
SCI
https://doi.org/10.1016/j.molliq.2022.119529
Elsevier
Journal of Molecular Liquids
2022
2022
17. Theoretical hydrolysis mechanism of anticancer Pt
(II) and Pd (II) dichloro complexes with N, N bidentate chelator in aqueous
medium and their molecular docking Chemical
Physics. Swarup Kumar Tarai, Saikat Mandal, RituparnaBhaduri, Angana Pan, Koyel Misra, Sankar Ch Moi* Journal of Chemical Physics
Vol. 553, page: 111390,
SCI
https://doi.org/10.1016/j.chemphys.2021.111390
Elsevier
https://doi.org/10.1016/j.chemphys.2021.111390
2022
2021
18. Development of Anticancer Activity of the Pt(II)
Complex with N-Heterocyclic Amine: Its In Vitro Pharmacokinetics with Thiol and
Thio-Ethers, DNA and BSA Binding, and Cell Cycle Arrest A. Pan, I. Mitra, S. Mukherjee, S. Ghosh, U.Chatterji, and S. C. Moi* ACS Applied Bio Materials
4,1, 853–868
SCI
https://doi.org/10.1021/acsabm.0c01374
American Chemical Society (ACS)
https://doi.org/10.1021/acsabm.0c01374
2021
2021
19. Development of Anticancer Activity of the Pt(II) Complex with
N-Heterocyclic Amine: Its In Vitro Pharmacokinetics with Thiol and Thio-Ethers,
DNA and BSA Binding, and Cell Cycle Arrest Angana Pan, Ishani Mitra, Subhajit Mukherjee, Subarna Ghosh, UrmiChatterji, and Sankar Chandra Moi* ACS Appl. Bio Mater.
4, 1, 853–868
SCI
https://dx.doi.org/10.1021/acsabm.0c01374
American Chemical Society (ACS)
ACS Appl. Bio Mater. 2021, 4, 853−868
2021
2021
20. Anticancer activity and cell death mechanism of
Pt(II) complexes: Their in vitro bio-transformation to Pt(II)-DNA adduct
formation and BSA binding study by spectroscopic method, 262,2021,120096. Rituparna Bhaduri, Subhajit Mukherjee, Ishani Mitra, Subarna Ghosh, UrmiChatterji, Subba Reddy Dodda, Sankar Ch. Moi* Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Vol.262 Page 120096
SCI
https://doi.org/10.1016/j.saa.2021.120096
Elsevier
https://doi.org/10.1016/j.saa.2021.120096
2021
2021
21. Anticancer activity and biomolecular interaction of
Pt (II) complexes: Their synthesis, characterisation and DFT study Appl Organomet Chem., 2021, e6506. Saikat Mandal, Venkata P Reddy B, Ishani Mitra, Subhajit Mukherjee, Swarup Kumar Tarai, RituparnaBhaduri, Angana Pan, Jagadeesh C Bose K, Goutam Kr Ghosh, Sankar Chandra Moi* Appl Organomet Chem.
Vol. e6506
SCI
10.1002/aoc.6506
Wiley
10.1002/aoc.6506
2021
2020
22. Drug reservoir mechanism of Pt(II)-sulfur
chelates based on pharmacokinetics of Pt(II) complex with thiols &
thio-ethers: An experimental and theoretical approach. S. K. Tarai, R. Bhaduri, S. Mukherjee, S. Mandal, V. P. Reddy B, S. C. Moi * Inorganica Chimica Acta
Vol. 517, Page: 120202
SCI
org/10.1016/j.ica.2020.120202
Elsevier
org/10.1016/j.ica.2020.120202
2020
2019
23. Influence of steric and electronic effect of carrier ligand on kinetics & mechanism of Pt(II) complexes with L-cysteine and its substituted derivatives: Their experimental and DFT-based theoretical study; S. Mahata, S. Mukherjee, I. Mitra, R. Bhaduri, K. Chandra,S. Mandal, W. Linert, and S. C. Moi* Inorg. Chem. Acta
498, 119117
SCI
Nhttps:// doi.org/10.1016/j.ica.2019.119117
Elsevier
2019
2019
24. Speciation Study of L-ascorbic Acid and its Chelated Cu(II)& Ni(II) Complexes: an Experimental and Theoretical Model of Complex Formation S. Mahata, I. Mitra, S. Mukherjee, V. Pera Reddy B., G. Kr. Ghosh, W. Linert and S. C. Moi* S. Afr. J. Chem.,
72, 229–236
SCI
https://doi.org/10.17159/0379-4350/2019/v72a30
South African Chemical Society
2019
2019
25. Synthesis and characterization of Pt(II)-based potent anticancer agents with minimum normal cell toxicity: their bio-activity and DNA-binding properties S. Mahata, S. Mukherjee, S. Kr Tarai, A. Pan, I. Mitra, S. Pal, S. Maitra and S. C. Moi* New J. Chem. RSC
43, 18767
SCI
10.1039/c9nj03108a
Royal Society of Chemistry
2019
2018
26. 25 number publication in last five yearsCurrent publications (Last 5 Years)
(26) Third order kinetics for interaction of glutathione with dinuclear Pd(II) complex and their mechanism, DNA binding and DFT study, A. Samanta, I. Mitra, S. Mukherjee, V. P. Reddy B., S. Mahata, A. Karmakar, G. K. Ghosh, W. Linert and S C. Moi*, J. Sol. Chem. (2018) 47:1139–1156.
(25) In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study, S. Mukherjee, I. Mitra, V. P. Reddy B., B. Misini, P. Das, W. Linert and S. C. Moi*, ChemistrySelect, (2018) 3, 3871– 3885.
(24) A New Bis(aquated) High Relaxivity Mn(II) Complex as an Alternative to Gd(III)-Based MRI Contrast Agent; B. Phukan, C. Mukherjee, U. Goswami, A. Sarmah, S. Mukherjee, S. K. Sahoo, and S. C. Moi, Inorg. Chem., (2018) 57 (5), 2631–2638.
(23) Synthesis, biological evaluation, substitution behaviour and DFT study of Pd(II) complexes incorporating benzimidazole derivative, I. Mitra, S. Mukherjee, V. P. Reddy B., B. Misini, P. Das, S. Dasgupta, W. Linert and S. C. Moi*, New J. Chem., (2018) 42, 2574 - 2589.
(22) A theoretical investigation on bio-transformation of third generation anti-cancer drug Heptaplatin and its interaction with DNA purine bases; V. P. Reddy B., S. Mukherjee, I. Mitra, S. C. Moi* , Chem. Phy. Letters, (2017) 690, 105–115.
(21) DNA/protein interactions, cell cycle arrest and apoptosis study of potent cytotoxic Pt(II) complexes with reduced side-effects; I. Mitra, S. Mukherjee, V. P. Reddy B., S. Kumar Chatterjee, S. Mukherjee, S. Ghosh, U. Chatterji, S. C. Moi*; J. Mol. Liquids (2017) 248, 515–526.
(20) Effect of Pt(II) complexes on cancer and normal cells compared to clinically used anticancer drugs: Cell cycle analysis, apoptosis and DNA/ BSA binding study, S. Mukherjee, I. Mitra, V. P. Reddy B., C. Fouzder, S. Mukherjee, S. Ghosh, U. Chatterji and, S. C. Moi*, J. Mol. Liquids, (2017) 247, 126–140.
(19) Hydrolysis theory based on density functional studies for cytotoxic Pt(II) and Pd(II) complexes with benzimidazole derivative, I. Mitra, V. P. Reddy B., S. Mukherjee, W. Linert and S. C. Moi*, Chem. Phy. Letters, (2017) 678, 250.
(18) Hydrolysis mechanism of (N, N) chelated cytotoxic Pt/Pd(II)-dichloro complexes: A theoretical approach, S. Mukherjee, V. P. Reddy B., I. Mitra, W. Linert and S. C Moi*, Chem. Phy. Letters (2017) 678, 241.
(17) Kinetic and mechanistic study of substitution on a cytotoxic PtII complex with biologically relevant thiols and a density functional study; I. Mitra; V. P Reddy B.; S. Mukherjee and S. C. Moi* Polyhedron (2017) 128, 46–56.
(16) Kinetics and mechanism of interaction of Pt(II) complex with bio-active ligands and in vitro Pt(II)-sulfur adduct formation in aqueous medium: bioactivity and computational study, A. Samanta, I. Mitra, V. P. Reddy B., S. Mukherjee, S. Mahata, W. Linert, B. Misini, A. Bhattacharjee, S. Dhabal, G. Kr. Ghosh & S. C. Moi* J. Coord. Chem., (2017) 70, 6, 1032–1052,
(15) In vitro kinetic based adduct formation mechanism of a cytotoxic Pt(II)complex with sulfur containing bio-relevant molecules and a theoretical approach, S. Mukherjee, V. P. Reddy B., I. Mitra, S. C. Moi*, Polyhedron (2017) 124, 251–261.
(14) Hydrolysis mechanism of anticancer drug lobaplatin in aqueous medium under neutral and acidic conditions: A DFT study, Venkata P. Reddy B., Subhajit Mukherjee, Ishani Mitra, Sujay Mahata, Wolfgang Linert, S. C. Moi* Chem. Phy. Letters, (2016) 663, 115–122.
(13) Cytotoxic, DNA binding and drug reservoir property of Pt(II)-Sulfur complexes: in-vitro kinetics, mechanism with bio-relevant molecules in aqueous medium and a theoretical approach, S. Mukherjee, I. Mitra, V. P. Reddy B., S. Mahata, J. C. Bose K., S. Dasgupta, W. Linert and S. C. Moi*, Polyhedron (2016) 119, 84–97.
(12) Benzimidazole based Pt(II) complexes with better normal cell viability than cisplatin: Synthesis, substitution behavior, cytotoxicity, DNA binding and DFT study, I. Mitra, S. Mukherjee, V. P. Reddy B., S. Dasgupta, J. C. Bose K, S. Mukherjee, W. Linert and S. C. Moi*, RSC Adv., (2016) 6, 76600
(11) A theoretical investigation on hydrolysis mechanism of biologically relevant Pt(II)/Pd(II) complexes with σ-donor and π-acceptor carrier ligand, V. P. Reddy B., I. Mitra, S. Mukherjee, P. S. Sengupta, S. Reddy D. and S. C. Moi* , Chem. Phy. Letters (2016) 657, 148.
(10) An experimental and theoretical approach on the kinetics and mechanism for the formation of a four membered (S, S) chelated Pt(II) complex, V. P. Reddy B., S. Mukherjee, I. Mitra, K. Misra, P. S. Sengupta, W. Linert, J. C. Bose K, G. K. Ghosh and S. C. Moi*, RSC Adv., (2016) 6, 18288.
(9) In vitro model reaction of sulfur containing bio-relevant ligands with Pt(II) complex: Their kinetics, mechanism, bioactivity and computational studies, S. Mukherjee, V. P. Reddy B., I. Mitra, R.N. Saha, J. C. Bose K., S. Reddy D., W. Linert and S. Ch. Moi*, RSC Adv., (2015) 5,76987
(8) PdII–PdII bonding interaction in dinuclear PdII complex with non-macrocyclic (O&N) chelates: Characterization, kinetics and DFT study, I. Mitra, G. K. Ghosh, S. Mukherjee, V. P. Reddy B., W. Linert, F. Kubel, X. Rocquefelte and S. C. Moi*, Polyhedron (2015) 89 101–109.
(7) Interaction of bio-relevant thio-ether and thiols with dinuclear Pd(II) complex: kinetics, mechanism, bioactivity in aqueous medium and molecular docking, K. Misra, G. K. Ghosh, I. Mitra, S. Mukherjee, V. P. Reddy B., W. Linert, B. Misini, J. C. Bose K, S. Mukhopadhyay and S. C. Moi*, RSC Adv. (2015) 5, 12454,
(6) Application of response surface methodology for optimization of reactive azo dye degradation process by Fentons’s oxidation, S. Dutta, A. Ghosh, S. C. Moi and R.N. Saha, Inter. J. Evr. Sci and Development, (2015) 11, 818-823,
(5) Mechanism of the Oxidation of thiosulphate with hydrogen peroxide catalyzed by Aqua-ethylenediaminetetracetato ruthanium(III), D Chatterjee, S Shome, N Jaiswal, S. C Moi - J. Mol. Catalysis A: Chemical, ( 2014).
(4) Kinetics and mechanism of biphasic substitution reactions of a platinum(II) complex with thioglycollic acid and 4-methyl-3-thiosemicarbazide in aqueous solution, K. Misra, I. Mitra, G. K. Ghosh, S. Mukherjee, B. Misini, W. Linert and S. C. Moi*, Transition Met Chem. (2014) 39:789–796.
(3) Ligand substitution reaction on a platinum(II) complex with bio-relevant thiols: kinetics,mechanism and bioactivity in aqueous medium, A. Samanta, G. K. Ghosh, I. Mitra, S. Mukherjee, J. C. Bose K, S. Mukhopadhyay, W. Linert and S. C. Moi*, RSC Adv., (2014) 4, 43516.
(2) Kinetics and Mechanism of the Interaction of Di-µ-hydroxobis(1,10-phenanthroline)dipalladium(II)Perchlorate with Thioglycolic Acid and Glutathione in Aqueous Solution, G. K. Ghosh, K. Misra, M. Baskim, W. Linert and S. C. Moi*, J Solution Chem. (2013) 42: 526–543.
(1)Interaction of Glutathione with Cis-(2-aminomethylpyridine)diaqua Platinum(II) perchlorate in aqueous medium: their Kinetics and mechanism, G. K. Ghosh, K. Mista, B. Misini, W. Linert and S. C. Moi*, Syn and React in Inorg, Met-Org, and Nano-Met Chem, (2013) 40: 285-292. A. Samanta, I. Mitra, S. Mukherjee, V. P. Reddy B., S. Mahata, A. Karmakar, G. K. Ghosh, W. Linert and S C. Moi* Third order kinetics for interaction of glutathione with dinuclear Pd(II) complex and their mechanism, DNA binding and DFT studyJournal of Solution Chemistry
47:1139–1156
SCI
https://doi.org/10.1007/s10953-018-0783-3
Springer nature
https://doi.org/10.1007/s10953-018-0783-3
2018
Conferences
ID
Details
Year
2019, Page-12-14
1.Better normal cell viability of newly Pt(II) complexes with N, N carrier ligands than cisplatin: Synthesis, DNA binding, anticancer property, cell death mechanism and molecular docking, Sixth International Conference, Indian Council of Chemists
Sixth International Conference, Indian Council of Chemists
2019, Page-12-14
2.Publications in National and International seminar or Conference (Last 5 years)
(1) Anticancer activity of newly designed Pt(II) and Pd(II) based complexes: their in vitro kinetics, bioactivity and theoretical study, RDC-2018, 17-19th Dec' 2018, NIT Durgapur , West Bengal, (Invited Lecture) in National Conference.
(2) Designing, Synthesis, characterization of Pt(II) and Pd(II) based anticancer agents: their kinetics, Bioactivity and theoretical study, TDB College Ranigan , West Bengal, , 5th April '2018 (Invited Lecture)in SERB-DST sponsored National seminar.
(3) Designing, Synthesis, characterization of Pt(II) and Pd(II) based anticancer agents: their kinetics, Bioactivity and theoretical study, Raiganj University, North Dinajpur, WB, 21st March'2018 (Invited Lecture), National symposium sponsored by DST, Government of India.
(4) Superior normal cell viability of Pt(II) complexes than cisplatin with benzimidazole as carrier ligand: Synthesis, DNA binding, anticancer property and computational study; 20-22nd September'2017, Science City, Kolkata, India, World Cancer Submit and Drug Discovery and Drug Delivery Congress (Invited Talk) (Best Speaker award with Gold Medal)
(5) A co-relation between corrosion and pollution in thermal power plant: a remedy to balance sustainable environment in Damodar Valley in India, 17-19 July'2017 (Invited Talk) at Canary Island, Spain.
(6) In vitro Pt(II)-sulfur adduct formation of cytotoxic Pt(II) complex with bio-relevant molecules in aqueous medium: DNA binding, drug reservoir property and a theoretical approach, International Conference on Recent Trends in Chemical Science (ICRCS-17) Jan.12-13, 2017 at Bikaner, (Invited talk)
(7) An experimental and theoretical approach on the kinetics and mechanism for the formation of a fourmembered (S, S) chelated Pt(II) complex and bioactivity studies. Venkata P. Reddy B. and Sankar Ch. Moi* (Oral presentation in RDC-2016 National conference NIT Durgapur from 4-6th Oct '2016, page no. 42)
(8) DNA binding and drug reservoir property of cytotoxic Pt(II)-sulfur complexes: substitution mechanism with bio-relevant molecules in aqueous medium and a theoretical approach, Subhajit Mukherjee and Sankar Ch. Moi* (Oral presentation in RDC-2016 National conference NIT Durgapur from 4-6th Oct '2016, page no. 40)
(9) Pt(II) complexes with benzimidazole as co-ligand possessing higher normal cell viability than cisplatin: Synthesis, substitution behavior, cytotoxicity, DNA binding and computational study, Ishani Mitra and Sankar Ch. Moi * (Oral presentation in RDC-2016 National conference NIT Durgapur from 4-6th Oct '2016, page no. 35)
(10) A case study on water conditioning and corrosion remedy of thermal power plants in river Damodar basin in eastern part of India: Sankar Ch. Moi, 3rd international congress on water, waste and energy Management, Rome, Italy 18-20th July'2016
(11) In vitro model reaction of sulfur containing bio-relevant ligands with Pt(II) complex: Their kinetics, mechanism, bioactivity and computational studies, Subhajit Mukherjee, Venkata P. Reddy B. and Sankar Ch. Moi*, p-182, 6th International Conference ICMG, I.I. Sc Bangalore, 2015.
(12) Substitution reactions of thio-ether and thiols on dinuclear Pd(II) and Pt(II) complexes: Kinetics, mechanism bio-activity and molecular Docking, I. Mitra, Koyel Misra, S. Mukharjee, Venkata P. Reddy B. and S. C. Moi, National Level Seminar on “Advance spectroscopy, Theoretical chemistry, synthesis, reactivity and structural evaluation”, 19-21st Feb’ 2015, Dept of Chemistry Burdwan University
(13) Application of response surface methodology for optimization of reactive azo dye degradation process by Fentons’s oxidation, S. Dutta, A. Ghosh, S. C. Moi and R.N. Saha*, 6th International conference on Environmental science and Development (ICESD-2015), Netherlands, 14th - 15th Feb ’2015, Amsterdam, Netherlands
(14) Substitution Reaction of thio-ether & thiols on dinuclear Pd(II) complex: Kinetics, Mechanism, Bioactivity & Docking, S. C. Moi, I. Mitra, S. Mukharjee and Venkata P. Reddy B., National Symposium, 23-24th Jan ’2015, NIT Sikkim
(15) Substitution reaction of thio-ether and thiols on dinuclear Pd(II) complex: Kinetics and Mechanism, I. Mitra, G. K. Ghosh and S. C. Moi, National conference on “Advance in Chemistry and their Biological and Industrial relevance (ACBIR-2014), 26th December’2014, NIT, Rourkrla, Odisa, India
(16) Substitution reaction of thio-ether and thiols on dinuclear Pd(II) complex: Kinetics, mechanism bio-activity and Docking, I. Mitra, S. Mukherjee, R. Mandal, S. Dutta and S. C. Moi , National conference organized by ICC, 15-17th Dec’ 2014, ISM Dhanbad, Jharkhand, India
(17) Rarely found third order reaction of biologically relevant molecules with d-µ-hydroxobis(2-aminomethyl pyridinedipalladium(II) ion in aqueous medium: Their kinetics and mechanism, S.C. Moi, G. K. Ghosh & Koyel Misra, International Mini-Symposium on “Recent Developments in Coordination Chemistry, 05/07/2013, Vienna University of Technology, Applied Synthetic Chemistry Dept., Getreidmarkt- 9/163, Vienna, Austria
(18) Third order reaction of biologically relevant molecules with d-µ-hydroxobis(2-aminomethyl pyridinedipalladium(II) ion in aqueous medium: Their kinetics and mechanism. G.K. Ghosh, I. Mitra, Koyel Misra, S. Mukharjee, and S. C. Moi, National conference on “Recent Developments in Chemistry-2013 (RDC-2013), 3-5th Oct’ 2013, Dept of Chemistry, NIT Durgapur, WB, India
Books
ID
Title
N/A
1.
N/A
Patents
ID
Details
Patent Filed Year
2023
1.
Titled: " Less toxic and more effective anticancer activity of pyridine along with few labile group-based Pt(II) complexes" (Application No:202331055248; dated: 17th August 2023)
Prof. Sankar Chandra Moi (Inventor)Miss. Rituparna Bhaduri (Research scholar)
Submitted
2023
Awards and Recognitions
a. Fellow member of Royal Society of Chemistry (FRSC), London (Memnership Number:717042)
b.Best Speaker award with Gold Medal' In International Conference of 'World Cancer Congress' and 'Drug Discovery and Drug Delivery' (Invited Talk) 20-22nd September'2017, Science City, Kolkata, India,
C. 'Outstanding Reviewer Award' in 2017-18 in International Journal (Elsevier).
Administrative Responsibilities
a. CPDA, Committee Member from March'2018.
b. Mentor of B. Tech students from July'2018.
c. 'Anti-ragging' Committee, Member from 2007 July to April'2016.
d. Warden of Hall #9 and Hall #11 frrom July'2007 to April'2016.
e. Industry Institute Interaction (III), Committee Member from 2013 to 2016.
f. DAC and DSC, Member of Department of Chemistry and other Departments.
Contact
Mobile : +91-9434788062 Email : sankar.moi@ch.nitdgp.ac.in
Miscellaneous
Collaboration:
(i) Prof. Wolfgang Linert, Dept of Applied synthetic Chemistry, Vienna University of Technology, Applied Synthetic Chemistry Dept. Vienna, Getreidmarkt 9/163, Vienna Austria, Europe. ) (From 2010 to till date)
(ii) Prof. Frank Kubel, Institute of Chemical Technologies and Analytics, Vienna University of Technology, Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt, 9/4. 1060 Vienna, Austria, Europe.
(iii) Prof. Xavier Rocquefelte Institut des Matériaux Jean Rouxel, France, Institut des Matériaux Jean Rouxel, Université de Nantes, UMR CNRS 6502, 2 rue de la Houssinière, BP 32229, 44322 Nantes, France.
(iv) Prof. U. Chatterjee, Department of Zoogly, Calcutta University, West Bengal, India
(v) Prof. C. Mukherjee, Department of Chemistry, IIT Guwahati. Assam, India
Membership in professional bodies:
Indian Chemical Society (F/7962- LM)
Indian Association for Cancer Research (LM-984)
Indian Council of Chemists (LM-1707)
Life member of NITDAA
Life member of Royal Society of Chemistry (Membership ID:717042)
Visited Countries for Research purpose
North Dakota State University, Fargo, USA, 2009
Vienna University of Technology, Vienna Austria, Europe, 2010
Vienna University of Technology, Vienna Austria, Europe, 2011
Vienna University of Technology, Vienna Austria, Europe, 2013
Amstardam, Natherland, Europe, 2015
Universita Torvargata, Rome Italy, Europe 2016
Gran Canaria Universita, Canary Island, Spain 2017.
France, Germany, Belgium, Luxenberg, Netherlands, Switzerland
ERP
