Biotechnology

Faculty Details

Ashish Bhattacharjee Associate Professor
Joined the Institute in 2013
abhattacharjee[dot]bt[at]nitdgp[dot]ac[dot]in
Education
  • 1999: Ph.D. in Biochemistry from Calcutta University, India
  • 1991: Post M.Sc. Associate in Biophysics from Saha Institute of Nuclear Physics. Calcutta, India
  • 1990: M.Sc. in Biochemistry from Calcutta University, India  
Work Experiences
  • From October 16, 2018 onwards  Associate Professor in the Department of Biotechnology, National Institute of Technology, Durgapur, West Bengal, India
  • From Dec 2012 Ramalingaswami fellow in the Department of Biotechnology, National Institute of Technology, Durgapur, West Bengal, India

 

  • Jan2012- Nov 2012 Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine (CCLCM) of Case Western Reserve University
  • July 2012-Nov 2012 Project Scientist/Instructor, Dept. of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation

 

  • May 2012-June 2012 : Visiting Scientist, Cleveland Clinic Foundation

 

  • May 2012-June 2012: Senior Research Associate, Dept. of Pathology, Case Western Reserve University

 

  • Dec 2010- April 2012: Project Scientist/Instructor, Dept. of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation

 

  • April 2004-Nov 2010: Research Associate, Department of Cell Biology,                                                           Lerner Research Institute, Cleveland Clinic Foundation

 

  • Jan 2000- March 2004: Post Doctoral Research Fellow,  Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation

 

  • April 1997 to Dec 1999: Research Associate,  IIT-BREF Biotek,Indian Institute of Technology, Kharagpur, India

 

  • Sep 1991 to Mar-1997: Research Scholar, Bose Institute,Calcutta, India
Research Interest

Monocyte/macrophage biology, Cellular and molecular signaling associated with Inflammation and inflammation-mediated cancer, cancer cell signaling

Projects

 

 

Title

Investigator

Co-investigator

Sponsered Agency

Duration

Status

1.  Oxidized Phospholipids in Vascular Pathobiology        

Principal Investigator:  Roy L. Silverstein, M.D.

NIH/NHLBI : P01 HL087018-01A1 Period of Support: 7/01/07 – 06/30/12

Project 3 Title:  Regulation of monocyte 15-lipoxygenase expression

PI of Project 3: Martha K. Cathcart, Ph.D.

 

This project will investigate the molecular pathways regulating the induction of 15LO gene expression in IL-13 activated human monocytes and interference by CD36. Role: Co-PI in Project 3

 

2. Project Title: Role of a novel signaling complex in regulating IL-13- induced 15- lipoxygenase expression in monocytes

 

Duration:  3 years (Funded in  May 2014), completed on 06-02-18

 

Sponsoring  Authority:  Scientific and Engineering Research Board (SERB), Department of Science and technology (DST), Govt. of India

 

Funds sanctioned:   Rs 47,39,000.00

 

Role: Principal Investigator

 

3. Research grant under Ramalingaswami  Re-entry fellowship

 

Project Title: Role of 15-Lipoxygenase in the Pathogenesis of several diseases

 

(Total 118.62902 Lakhs including Contingency/Research Grant of 42.5 lakhs for the next 7 years) funded by the Dept. of Biotechnology, Govt. of India

Duration: 10th December, 2012  to 9th December, 2019.

 

4. Project Title: Fish fat transformation during processing, preservation, braising and its nutritional consequences in terms of food value

 

Duration:  3 years (Funded in  January,  2017)

 

Sponsoring  Authority:  Department of Science and Technology, Government of West Bengal

 

Funds sanctioned:   Rs 32,18,200.00

 

Role: Co-PI (PI: Jitamanyu ChakrabartyDept. of chemistry, NIT-Durgapur).

 

5. Project Title:  Role of adenosine monophosphate activated protein kinase (AMPK) activators in reducing cancer cell aggressiveness

 

Sponsoring  Authority:  Department of higher education, Science & Technology and B iotechnology, Govt. of West Bengal.

 

Duration:  3 years (Funded in  March,  2019)

Role: Principal Investigator

 

Funds sanctioned:   Rs 20,75,647.00

 

6. Project Title:      Regulation of MCP-1-induced calcium-independent

phospholipase A2 (iPLA2)-dependent monocyte migration

 

Sponsoring  Authority: Dept. of Biotechnology, Govt. of India

 

Duration:  3 years (Funded in  May,  2019)

Role: Principal Investigator

Funds sanctioned:   Rs 51,17,300.00 

       

Ongoing

 

 

Teachings

Contribution in Teaching:

 

B.Tech.

M.Tech

Odd Semester

Even Semester

Odd Semester

Even Semester

BTC 301

Cell Biology and Genetics (4)

BT 403

Cell Biology (3)

BT9032

Advanced Cell Signaling (4)

BT9020

Metabolic Engineering (4)

BTS 381

Biochemistry Lab

BT451

Biochemistry Lab

 

 

BTC01

(Life Science)

BTC01

(Life Science)

 

 

Contribution to the development of Syllabus/Curricula

  

Undergraduate

 

I have developed the syllabus of Biochemical Analysis and Instrumentation theory and sessional subject for 3rd semester (BT302 and BT352) B. Tech. course. I have introduced a new elective cell signaling (BT 613) for 6th semester B.Tech course and  have developed the syllabus for the subject.

 

 

Postgraduate

 

I have introduced a new elective Advanced cell signaling (BT 9032) for  first year M.Tech course and  have developed the syllabus for the subject.

 

New projects introduced in the laboratories

 

I have introduced all the experiments, ten in number for the new course entitled " Biochemical Analysis and Instrumentation Laboratory"  for  B.Tech (BT352) 3rd semester students. I am developing the undergraduate laboratory for the new course.

PG Programme: Project work of eight M.Tech students completed (till 2017-18), One M.Tech student (2018-19) is in progress, Role: Principal Supervisor

 

M.Tech Project work supervised

1. Project Title: Long chain fatty acids (LCFs) induce Monoamine Oxidase A (MAO-A) in A549 cells.

Submitted by: Dhanalakshmi J,  May 2018

2. Project Title: Adenosine Monophosphate-Activated Protein Kinase (AMPK) activation reduces cancer cell aggressiveness by downregulating  Monoamine Oxidase A (MAO-A).

Submitted by: Tuhina Prasad,  May 2018

3. Project Title: Role of Src kinase in regulating the migration of monocytic cells

Submitted by: Kowsalya T,  May 2017

4. Project Title: 15-Lipoxygenase mediated apoptosis in cancer cells

Submitted by: Aditi Arya,  May 2017

5. Project Title: Regulatory pathways that control Monoamine Oxidase A (MAO-A) expression in cancer cells

Submitted by: Arpa Ghoshal,  May 2016

6. Project Title: Control of MCP-1-mediated monocyte migration by a kinase cascade

Submitted by: Bala Sinjini Sib Sankar,  May 2016

7. Project Title: Stat1: A Regulator of Monoamine Oxidase A (MAO-A) activity

Submitted by: Parul,  May 2015

8. Project Title: TH2 cytokine IL-13 induces Monoamine Oxidase A (MAO-A) expression in A549 Cells

Submitted by: Priyanka Kumari,  May 2014

 

 

 

3. UG Programme: Project work of twentyseven students from B. Tech (BT) 7th semester  (till 2017-18) completed . Six ongoing. Role: Principal Supervisor

 

 

 

 

Summer Project workof B.Tech. Biotechnology students:

 

Three summer students (Ms. Pradeepta Khan in 2015 and Debapriya Panja in 2016 from the Dept. of Biotechnology, Heritage Institute of Technology and Ms Dayita Kundu from St. Xavier's college, Kolkata in 2017) completed their summer project work under my supervision.

UG / PG Students

Data Not Found!

Doctoral Students

Pritam Biswas

Pritam Biswas

Senior research fellow
Institute scholar (SRF) , Inflammation and cancer biology
Pritam Biswas

Pritam Biswas

Senior research fellow

Institute scholar (SRF) , Inflammation and cancer biology

Surbhi Swaroop

Surbhi Swaroop

Ph.D. (Ongoing)
Institute Fellow (JRF) Thesis Title: Regulation of 15-Lipoxygenase expression and function
Surbhi Swaroop

Surbhi Swaroop

Ph.D. (Ongoing)

Institute Fellow (JRF) Thesis Title: Regulation of 15-Lipoxygenase expression and function

Sukhamoy Dhabal

Sukhamoy Dhabal

Ph.D. (Ongoing)
CSIR -SRF Thesis Title: Stat-dependent expression and function of Monoamine Oxidase-A (MAO-A) In IL-13-activated A549 cells
Sukhamoy Dhabal

Sukhamoy Dhabal

Ph.D. (Ongoing)

CSIR -SRF Thesis Title: Stat-dependent expression and function of Monoamine Oxidase-A (MAO-A) In IL-13-activated A549 cells

Pradip Das

Pradip Das

Ph.D. (Ongoing)
NET (CSIR) qualified Thesis Title: "Role of Src kinase and Pyk2 in Monocyte migration"
Pradip Das

Pradip Das

Ph.D. (Ongoing)

NET (CSIR) qualified Thesis Title: "Role of Src kinase and Pyk2 in Monocyte migration"

Suchandra Pal

Suchandra Pal

Ph.D. (Ongoing)

Suchandra Pal

Suchandra Pal

Ph.D. (Ongoing)


Projects

Sl.No. Title Name of the PI Name of the CoPIs Funding Agency Amount (Rs.) Project Type Project Status Date of Initiation Date of Completion
1 Developing a machine learning based platform for defining and mechanistic understanding of chemo-drug response/resistance biomarkers for lung cancer and subsequent validation with patient data from TCGA database Bhattacharjee,A De, D. Indian Council of Medical Research (ICMR), New Delhi, Govt. of India 2,239,932 Sponsored Ongoing 2022
2 Role of adenosine monophosphate activated protein kinase (AMPK) activators in reducing cancer cell aggressiveness Bhattacharjee,A Chaudhuri S, Chatterjee, S. Department of higher education, Science & Technology and Biotechnology, Govt. of West Bengal. 2,076,000 Sponsored Ongoing 2019
3 Regulation of MCP-1-induced calcium-independent phospholipase A2 (iPLA2)-dependent monocyte migration Bhattacharjee,A Ghosh, M. Dept. of Biotechnology (DBT), Govt. of India 5,707,000 Sponsored Completed 2019 2022
4 Fish fat transformation during processing, preservation, braising and its nutritional consequences in terms of food value Chakrabarty, J Bhattacharjee, A. DEPARTMENT OF SCIENCE AND TECHNOLOGY, GOVERNMENT OF WEST BENGAL 3,218,200 Sponsored Completed 2017 2020
5 Fish fat transformation during processing, preservation, braising and its nutritional consequences in terms of food value Chakrabarty, J Bhattacharjee, A. DEPARTMENT OF SCIENCE AND TECHNOLOGY, GOVERNMENT OF WEST BENGAL 3,218,200 Sponsored Completed 2017 2020
6 ROLE OF A NOVEL SIGNALING COMPLEX IN REGULATING IL-13 INDUCED 15-LIPOXYGENASE EXPRESSION IN MONOCYTES Bhattacharjee,A Mukhopadhyay , S.S. SERB, Department of Science and technology (DST), Govt. of India 4,739,000 Sponsored Completed 2014-06-10 2018
7 ROLE OF 15-LIPOXYGENASE (15-LOX) IN THE PATHOGENESIS OF SEVERAL DISEASES Bhattacharjee, A NA DEPT.OF BIOTECHNOLOGY, GOVT. OF INDIA (RESEARCH GRANT UNDER RAMALINGASWAMI RE-ENTRY FELLOWSHIP) 4,250,000 Sponsored Completed 2012 2018

Projects

Sl.No. Title Name of the PI Name of the CoPIs Funding Agency Amount (Rs.) Project Type Project Status Date of Initiation Date of Completion
1 Developing a machine learning based platform for defining and mechanistic understanding of chemo-drug response/resistance biomarkers for lung cancer and subsequent validation with patient data from TCGA database Bhattacharjee,A De, D. Indian Council of Medical Research (ICMR), New Delhi, Govt. of India 2,239,932 Sponsored Ongoing 2022
2 Role of adenosine monophosphate activated protein kinase (AMPK) activators in reducing cancer cell aggressiveness Bhattacharjee,A Chaudhuri S, Chatterjee, S. Department of higher education, Science & Technology and Biotechnology, Govt. of West Bengal. 2,076,000 Sponsored Ongoing 2019
3 Regulation of MCP-1-induced calcium-independent phospholipase A2 (iPLA2)-dependent monocyte migration Bhattacharjee,A Ghosh, M. Dept. of Biotechnology (DBT), Govt. of India 5,707,000 Sponsored Completed 2019 2022
4 Fish fat transformation during processing, preservation, braising and its nutritional consequences in terms of food value Chakrabarty, J Bhattacharjee, A. DEPARTMENT OF SCIENCE AND TECHNOLOGY, GOVERNMENT OF WEST BENGAL 3,218,200 Sponsored Completed 2017 2020
5 Fish fat transformation during processing, preservation, braising and its nutritional consequences in terms of food value Chakrabarty, J Bhattacharjee, A. DEPARTMENT OF SCIENCE AND TECHNOLOGY, GOVERNMENT OF WEST BENGAL 3,218,200 Sponsored Completed 2017 2020
6 ROLE OF A NOVEL SIGNALING COMPLEX IN REGULATING IL-13 INDUCED 15-LIPOXYGENASE EXPRESSION IN MONOCYTES Bhattacharjee,A Mukhopadhyay , S.S. SERB, Department of Science and technology (DST), Govt. of India 4,739,000 Sponsored Completed 2014-06-10 2018
7 ROLE OF 15-LIPOXYGENASE (15-LOX) IN THE PATHOGENESIS OF SEVERAL DISEASES Bhattacharjee, A NA DEPT.OF BIOTECHNOLOGY, GOVT. OF INDIA (RESEARCH GRANT UNDER RAMALINGASWAMI RE-ENTRY FELLOWSHIP) 4,250,000 Sponsored Completed 2012 2018

Projects

Sl.No. Title Name of the PI Name of the CoPIs Funding Agency Amount (Rs.) Project Type Project Status Date of Initiation Date of Completion
Indexing

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Awards and Recognitions
  • 2012    Recipient of Ramalingaswami Re-entry Fellowship from Dept. of Biotechnology, Govt. of India
  • 2012: Recipient of Elsa Albrecht RA/PS Award from Dept. of Cell Biology, Cleveland Clinic, (Best research publication from Cell Biology Dept., Lerner Research Institute, Cleveland Clinic)
  • 2009: Recipient of Travel Award from Gordon Research Conference on Atherosclerosis, Tilton School, Tilton, New Hampshire
  • 2006: Recipient of F. Merlin Bumpus Junior Investigator Finalist Award in Basic Science from Cleveland Clinic
  • 2006: Recipient of Junior Investigator Finalist Award in Vascular Biology from The North American Vascular Biology Organization (NAVBO) at Experimental Biology, San Francisco, California, USA
  • 2005: Recipient of Travel Award from Gordon Research Conference on Atherosclerosis, University of New England in Biddeford, ME
  • 1981: Recipient of National Scholarship from Govt. of India
Administrative Responsibilities

a) Organization of Departmental seminars

 

b) Member of  DST-FIST Committee

 

c) Member of Departmental Academic Committee

 

d) Member of Departmental Research Program Committee

Contact

Mobile : +91-9433924013, 9434788034
Email : ashish.bhattacharjee@bt.nitdgp.ac.in

Miscellaneous

PUBLISHED ABSTRACTS

 

  • Mulya A, Bhattacharjee A, Cathcart MK (July, 2009), The Mitogen-Activated Protein Kinases ERK1/2 Activity is Essential for Interleukin-13-Induced 15-Lipoxygenase Expression in Primary Human Monocytes, Abstract from Annual Conference on Arteriosclerosis,Thrombosis, and Vascular Biology 2009, Arterioscler Thromb Vasc Bio. Vol 29, No. 7, July 2009; page e24 (P83).
  • Bhattacharjee A, Pal S, Feldman GM, Cathcart MK(April 2008), Extracellular Regulatory Kinase (ERK1/2) Regulates 15-lipoxygenase Expression in Primary Human Monocytes. FASEB Journal, Vol 22, Meeting abstracts, April 2008.  In Vascular Biology: Atherosclerosis and other vascular diseases (under Pathology), Meeting abstract No. 902.5
  • Bhattacharjee A, Pal S, Feldman GM, Cathcart MK (June, 2007), The role of Src kinase in regulating 15-lipoxygenase expression in primary human monocytes, Abstract from 8th Annual Conference on Arteriosclerosis,Thrombosis, and Vascular Biology, Arterioscler Thromb Vasc Bio. Vol 27, Issue 6, June 2007; page e117 (P457) under (e35-e137).
  • Bhattacharjee A, Xu B, Frank DA, Feldman GM, Cathcart MK (April, 2006), Monocyte 15-Lipoxygenase expression is regulated by a novel cytosolic signaling complex with PKCd and tyrosine phosphorylated Stat3, Abstract from Experimental Biology meeting 2006. The FASEB journal. 2006; 20 (4), Part I, A635.
  • Bhattacharjee A, Xu B, Roy B, Frank DA, Feldman GM, Cathcart MK (April, 2003), PKCdelta regulates IL-13-induced Stat3 serine (727) phosphorylation and 15-lipoxygenase gene expression, Abstract from Experimental Biology meeting 2003.The FASEB journal. 2003; 17 (5), Part II, A1354.
  • Xu B, Bhattacharjee A, Roy B, Xu HM, Frank DA, Feldman GM, Cathcart MK (April, 2003), IL-13 induction of 15-Lipoxygenase gene expression requires p38 MAPK-dependent serine phosphorylation of Stat1 and Stat3, Abstract from Experimental Biology meeting 2003.The FASEB journal. 2003; 17 (5), Part II, A1354.
  • Roy B, Bhattacharjee A, Cathcart MK (April, 2001),    Involvement of MAP-Kinases and PKCd in IL-13-mediated induction of 15-lipoxygenase in primary human monocytes, Abstract from 2nd Annual Conference on Arteriosclerosis,Thrombosis, and Vascular Biology, Arterioscler Thromb Vasc Bio.2001; 21(4), 692.
  • Ghosh SK, Bhattacharjee A, Maiti MK, Basu A, Ghosh D, Ghosh S, Sen SK (April, 2001), Prospects of genetic engineering of fatty acid composition of Indian mustard oil, Abstract: International Conference on New Horizons in Biotechnology (NHBT-2001) Trivandrum, India

MEETING ATTENDED/PRESENTATION 

2nd Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Arlington, Virginia, April 2001 (Presented poster).

  • Experimental Biology 2003, San Diego, California, April 2003 (Presented poster).
  • Gordon Research Conference on Atherosclerosis, University of New England in Biddeford, ME from June 19-24, 2005. Presented a poster entitled “Stat3 tyrosine phosphorylation is required for its association with PKCd and serine 727 phosphorylation in IL-13-induced human blood monocytes”.
  • Experimental Biology 2006, San Francisco, California, April 2006 (Invited for a lecture and a poster presentation).

·Presented Poster in 26th Annual Cleveland Clinic Research Day (16 th October, 2006) conducted by Lerner Research Institute, Cleveland Clinic.

·8th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Chicago, Illinois, April 19-21, 2007 (Presented poster).

  • Experimental Biology 2008, San Diego, California, April 5-9, 2008 (Presented poster).
  • Gordon Research Conference on Atherosclerosis, Tilton School, Tilton, New Hampshire from June 21-26, 2009. Presented a poster entitled “Role of a Src-MKK3/6-p38MAPK Signaling Cascade in Regulating both 15-lipoxygenase and CD36 Expression in Primary Human Monocytes”.
  • Presented my research progress in the fellow’s seminar series conducted by the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic in each year since 2000. 

 

MEMBERSHIP IN SOCIETIES/ASSOCIATION

 

  • American Society of investigative pathology
  • American Heart Association
  • North American Vascular Biology Organization
  • American Society for Biochemistry and Molecular Biology (Member ID: 61340, Validity up to August 05, 2021)
  • American Association of Immunologists (AAI) (Member ID: 00250981, Validity up to Dec 2020)

EDITOR  

Inflammation and Cell Signaling (Published from Houston, Texas, United States)

Review Editor of Frontiers in Cellular Biochemistry (Published from Lausanne, Switzerland)

 

REVIEWER

PLOs one, Frontiers in Molecular Biosciences, British Journal of Pharmacology, Cellular Physiology and Biochemistry, Journal of Lipid Research, Oxidative Medicine and Cellular Longevity, Nature Communications, Frontiers Cell and Developmental Biology, EMBO Molecular Medicine

 


 


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